RHODOS - Rescue of Hereditary Optic Disease Outpatient Study): Eighty-five patients with one of the three primary LHON mutations and onset of symptoms within the last five years were randomized to receive 300mg of idebenone three times a day for 24 weeks, or placebo. Though the study did not reach its primary endpoint, best recovery in visual acuity, post hoc analysis revealed improvement in visual acuity seen particularly in those individuals with discordant vision between eyes. Those with the G11778A and G3460A seemed to benefit more;
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