====== Neuroblastoma ======
  * 2-3% of patients with neuroblastoma have opsoclonus-myoclonus-ataxia syndrome 
  * 50% of those with [[opsoclonus|opsoclonus]] have neuroblastoma
  * Children with or without tumors cannot be distinguished by neurologic symptoms
===== Associated symptoms =====
  * Myoclonus
  * Ataxia 
  * drooling
  * refusal to walk or sit
  * speech problems
  * decreased muscle tone
  * rage attacks
  * inability to sleep
===== Survival =====
  * 100% at 3 years in those presenting with [[opsoclonus|opsoclonus]]
  * 78% in those presenting with [[horner_syndrome_and_cocaine|Horner syndrome]]
  * 11% in those with orbital metastasis
===== Late problems =====
  * [[opsoclonus|Opsoclonus]] typically resolves
  * Cognitive and speech delays
  * Motor problems:  myoclonus, ataxia, dysarthria, hypotonia
  * Cerebellar atrophy on later MRI

===== Etiology =====
Tumor producing peptide that is neurotoxic to oculomotor system or anticerebellar antibody