====== Orkambi ======
(lumacaftor/ivacaftor)

  * Drug used in the treatment of Cystic Fibrosis
  * transmembrane conductance regulator potentiator 
  * Approved for ages 2 and older
  * [[https://www-bmj-com.proxy.lib.uiowa.edu/content/361/bmj.k1783|Review Article]]

==== Cataracts with Lumacaftor/Ivacaftor ====
  * Cataracts were found in juvenile rats in pre-clinical toxicology studies
  * Cataracts have been discovered in a few children taking this drug. The concomitant use of steroids or other pre-existing coniditions could not be excluded. 
    * [[https://www.atsjournals.org/doi/10.1164/rccm.201608-1754OC#_i11|Lumacaftor/Ivacaftor in Patients Aged 6–11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR]]
    * [[https://adc-bmj-com.proxy.lib.uiowa.edu/content/103/1/68|The impact of 12 months treatment with ivacaftor on Scottish paediatric patients with cystic fibrosis with the G551D mutation: a review]]
  * Drug manufacturer recommends baseline and follow-up eye examinations of unspecified interval or duration 
    * [[https://pi.vrtx.com/files/uspi_lumacaftor_ivacaftor.pdf|Prescribing Information]]

{{tag>drugs}}