====== Retinoblastoma International Classification ======

^ Group  ^ Summary                   ^ Sub-Group  ^ Specific Features                                                                                                                                                                                                                   ^ Usual Treatment                                     ^
|  A     | Small Tumor               |            | Tumor ≤ 3mm (in greatest dimensions)                                                                                                                                                                                                | Focal Laser or Cryotherapy                          |
|  B     | Large Tumor / Poor location              |            | Tumor >3mm or macular retinoblastoma location (≤3 mm to foveola) juxtapapillary retinoblastoma location (≤1.5 mm to disc) additional subretinal fluid (≤3 mm from margin)                                                           | Chemoreduction, Plaque therapy                      |
|  C     | Focal seeds               | C1         | Subretinal Seeds ≤ 3 mm from tumor                                                                                                                                                                                                  | Chemoreduction, Plaque therapy                      |
| :::    | :::                       | C2         | Vitreous Seeds ≤ 3 mm from tumor                                                                                                                                                                                                    | :::                                                 |
| :::    | :::                       | C3         | Both Subretinal and vitreous seeds ≤ 3mm from tumor                                                                                                                                                                                 | :::                                                 |
|  D     | Diffuse Seeds             | D1         | Subretinal seeds >3 mm from tumor                                                                                                                                                                                                   | Chemoreduction IV or IAC, enucleation (unilateral)  |
| :::    | :::                       | D2         | Vitreous seeds >3 mm from tumor                                                                                                                                                                                                     | :::                                                 |
| :::    | :::                       | D3         | Both subretinal and vitreous seeds > 3 mm from tumor                                                                                                                                                                                | :::                                                 |
|  E     | Extensive retinoblastoma  |            | Extensive tumor occupying >50% globe or neovascular glaucoma, opaque media from hemorrhage in anterior chamber, vitreous or subretinal space invasion of postlaminar optic nerve, choroid (>2 mm), sclera, orbit, anterior chamber  | Enucleation                                         |

{{tag>retinoblastoma}}