====== Doxycycline for Blepharokeratoconjunctivitis in Children ======
  * Avoid in younger than age 8 due to concern about teeth yellowing and enamel hypoplasia

===== Dosing =====
  * 40-200 mg/day have been used
    * most evidence for 100 mg QD x 3 months or 50 mg QD x 8 months 
  * Duration: 4 weeks to 8 months 
===== Side Effects =====
  * Skin: photosensitivity and lesions
  * GI: emesis, diarrhea, dyspepsia 
  * Stevens-Johnsons syndrome
  * Supratheraputic INR in those taking coumadin 
===== Contraindications =====
  * pregnancy
  * nursing mothers
  * <8 years old

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[[https://www.aaojournal.org/article/S0161-6420(15)01303-2/pdf|Oral Antibiotics for Meibomian Gland-Related Ocular Surface Disease]]\\
[[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390373/|The end of a dogma: the safety of doxycycline use in young children for malaria treatment]]
{{tag>drugs, blepharitis}}