Inhibits nucleic acid synthesis and by so doing, it inhibits cell proliferation
Folate analogue and inhibits dihydrate folate reductase
Dosing and route of administration
7.5 to 25 mg once per week
must also give folic acid
Has been used via intravitreal injection
Hardwig PW, Pulido JS, Erie JC, Baratz KH, Buettner H. Intraocular methotrexate in ocular diseases other than primary central nervous system lymphoma. Am J Ophthalmol. 2006 Nov; 142(5):883–5. PubMed abstract
Taylor SR, Habot-Wilner Z, Pacheco P, Lightman SL. Intraocular methotrexate in the treatment of uveitis and uveitic cystoid macular edema. Ophthalmology. 2009 Apr; 116(4):797–801. PubMed abstract
Side Effects
Hepatotoxicity- Liver function should be monitored