Autoimmune disease of that affects the lacrimal and salivary glands causing dryness of the ocular surface and mucous membranes. It often seriously affects other organ systems, such as the lungs, kidneys, and nervous system.
| Item | Weight/Score |
| Anti-SSA / Ro antibody positivity | 3 |
| Focal lymphocytic sialadenitis with a focus score of ≥ 1 foci / 4 mm² | 3 |
| Abnormal ocular staining score of ≥ 5 (or van Bijsterveld score of ≥ 4) | 1 |
| Shirmer's test (no local anesthetic) result of ≤ 5mm / 5 minutes | 1 |
| Unstimulated salivary flow rate of ≤ 0.1 ml/minute | 1 |