Table of Contents

Classification of Uveitis

(Standardization of Uveitis Nomenclature (SUN) working group scheme)

Anatomic Classification

Type Primary Site of Inflammation Includes
Anterior Anterior Chamber Iritis, Iridocyclitis, Anterior cyclitis
Intermediate Vitreous Pars Planitis, Posterior cyclitis, Hyalitis
Posterior Retina or Choroid Focal, multifocal or diffuse choriditis; Chorioretinitis; Retinochoroiditis, Retinitis, Neuroretinitis
Panuveitis Anterior Chamber, Vitreous, and Retina or Choroid

Grading of Anterior Chamber Cells

Grade Cells in 1mm x 1 mm slit beam
0 <1
0.5 + or Trace 1-5
1+ 6-15
2+ 16-25
3+ 26-50
4+ >50

Grading of Anterior Chamber Flare

Grade Description
0 None
1+ Faint
2+ Moderate (iris and lens details clear)
3+ Marked (iris and lens details hazy)
4+ Intense (fibrin or plastic aqueous)

Descriptors of Uveitis

Category Descriptor Comment
OnsetSudden
Insidious
DurationLimited≤3 months duration
Persistent≥3 months duration
CourseAcuteEpisode of sudden onset and limited duration
RecurrentRepeat episodes separated by periods of inactivity without therapy ≥3 months duration
ChronicPersistent with relapse <3 months after discontinuing therapy

Grading Vitreous Cells

Grade Number of Vitreous cells
0 No cells
0.5+ or trace 1-10
1+ 11-20
2+ 21-30
3+ 31-100
4+ >101

Grading Vitreous Flare

Grade Descriptors
0No inflammation present
0.5+Trace inflammation present (slight blurring of optic nerve margins, normal striations and reflex of nerve fiber layer cannot be visualized)
1+Mild blurring of the optic nerve and retinal vessels
2+Optic nerve visible, borders blurred markedly
3+Optic nerve head not visible
4+

Activity of Uveitis

Term Definition
InactiveGrade 0 cells (in anterior chamber)
Worsening activity2-step increase in level of inflammation (i.e., anterior chamber cells, vitreous haze or increase from grade 3+ to 4+)
Improved activity2-step decrease in level of inflammation (i.e., anterior chamber cells, vitreous haze or decrease to grade 0)
RemissionInactive disease for ≥3 months after discontinuing all therapy for eye disease

Reference

The Standardization of Uveitis Nomenclature (SUN) Working Group. Am J Ophthalmol 2005;140:509-516