Show pagesourceExport to PDFBack to top Table of Contents Brimonidine (Alpha-2 Agonist) Main Effects Side Effects Brimonidine (Alpha-2 Agonist) Main Effects Lowers IOP Pupil constriction Effect of brimonidine tartrate ophthalmic solution 0.2% on pupil size in normal eyes under different luminance conditions. McDonald et al. Journal of Cataract & Refractive Surgery 2021;27(4):560-564 Side Effects CNS depression Hypotension Apnea Lethargy Hypotonia Hypothermia drugs, side effect drugs side effect