Orkambi
(lumacaftor/ivacaftor)
- Drug used in the treatment of Cystic Fibrosis
- transmembrane conductance regulator potentiator
- Approved for ages 2 and older
Cataracts with Lumacaftor/Ivacaftor
- Cataracts were found in juvenile rats in pre-clinical toxicology studies
- Cataracts have been discovered in a few children taking this drug. The concomitant use of steroids or other pre-existing coniditions could not be excluded.
- Drug manufacturer recommends baseline and follow-up eye examinations of unspecified interval or duration