- cause vasoconstriction, mydriasis and uterine contractions
- Phenylepherine (neoynepherine): Alpha-1 receptor agonist
- Other similar drugs: Dipivefrin, naphazoline
- have more effects on CNS
- Apraclonadine: weakly binds to Alpha-1 receptors
- Will cause dilation in Horner syndrome pupil due to this binding effect and upregulation of the receptor that occurs 2-5 days after sympathetic block
- Bromonidine (Alphagan P) is similar with less Alpha-1 effect on pupil
- Cocaine: blocks reuptake of norepinephrine
- causes dilation in normal pupil but not in a Horner syndrome pupil
- Amphetamine: causes release of and blocks reuptake of norepinepherine
- causes dilation in normal pupil but not in a Horner syndrome pupil.
oculoman